Tetraphenylphosphonium
Title: Tetraphenylphosphonium
CAS Registry Number: 18198-39-5
Additional Names: TPP+
Molecular Formula: [C24H20P]+
Literature References: Membrane-permeable, lipophilic cation. Prepd as bromide: J. Dodonov, H. Medox, Ber. 61B, 907 (1928); D. B. Denney, F. J. Gross, J. Org. Chem. 32, 3710 (1967). As analytical reagent for identification of metals and their salts: H. H. Willard, L. R. Perkins, Anal. Chem. 25, 1634 (1953); R. Neeb, Z. Anal. Chem. 154, 17 (1957). Enhanced metal -TPP+ complex determn by extraction-visible spectrophotometry: M. Siroki, L. Maric, ibid. 276, 371 (1975). Solvent interactions: J. F. Coetzee, W. R. Sharpe, J. Phys. Chem. 75, 3141 (1971). Use in determn of membrane potential in liposomes: K. Nakazato et al., Biochim. Biophys. Acta 946, 143 (1988); in hepatocytes: S. Saito et al., ibid. 1111, 221 (1992). NMR determn of TPP+ driven potential: C. M. Franzin, P. M. Macdonald, Biochemistry 35, 851 (1996).
Use: As analytical reagent for metals and their salts. As a probe for measuring membrane potential.

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