Ticrynafen
Title: Ticrynafen
CAS Registry Number: 40180-04-9
CAS Name: [2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy]acetic acid
Additional Names: [2,3-dichloro-4-(2-thenoyl)phenoxy]acetic acid; [2,3-dichloro-4-(2-thiophenecarbonyl)phenoxy]acetic acid; tienilic acid; thienylic acid
Manufacturers' Codes: ANP-3624; CE-3624; SKF-62698
Trademarks: Diflurex (Anphar-Rolland); Selacryn (SKB)
Molecular Formula: C13H8Cl2O4S
Molecular Weight: 331.17
Percent Composition: C 47.15%, H 2.43%, Cl 21.41%, O 19.32%, S 9.68%
Literature References: A heterocyclic derivative of phenoxyacetic acid. Prepn: J. Godfroid, J. Thuillier, DE 2048372; US 3758506 (1971, 1973 both to C.E.R.P.H.A.) and FR 2115042 (1972 to C.E.R.P.H.A.). Synthesis and pharmacology: G. Thuillier et al., Eur. J. Med. Chem. 9, 625 (1974). Pharmacokinetics in healthy volunteers: A. L. Kerremans et al., Eur. J. Clin. Pharmacol. 22, 515 (1982). Comparative study in hypertensive patients: B. T. Emmerson et al., ibid. 203. Hepatotoxicity study: J. W. Manier et al., Am. J. Gastroenterol. 77, 401 (1982).
Properties: Crystals from 50% ethanol, mp 148-149°; also reported as mp 157°. LD50 in mice (mg/kg): 225 i.v., 1275 orally (US 3758506).
Melting point: mp 148-149°; mp 157°
Toxicity data: LD50 in mice (mg/kg): 225 i.v., 1275 orally (US 3758506)
Therap-Cat: Diuretic; uricosuric; antihypertensive.
Keywords: Antihypertensive; Diuretic; Uricosuric.

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