Tioclomarol
Title: Tioclomarol
CAS Registry Number: 22619-35-8
CAS Name: 3-[3-(4-Chlorophenyl)-1-(5-chloro-2-thienyl)-3-hydroxypropyl]-4-hydroxy-2H-1-benzopyran-2-one
Additional Names: 3-[5-chloro-a-(p-chloro-b-hydroxyphenethyl)-2-thenyl]-4-hydroxycoumarin
Trademarks: Apegmone (Lipha)
Molecular Formula: C22H16Cl2O4S
Molecular Weight: 447.33
Percent Composition: C 59.07%, H 3.61%, Cl 15.85%, O 14.31%, S 7.17%
Literature References: Slow-acting anticoagulant, related structurally to warfarin, q.v. Prepn: E. Boschetti et al., ZA 6707267 corresp to US 3574234 (1968, 1971 both to Lipha). Synthesis and anticoagulant activity: eidem, Chim. Ther. 7, 20 (1972).
Properties: White cryst from methanol, mp 104°.
Melting point: mp 104°
Therap-Cat: Anticoagulant.
Keywords: Anticoagulant.

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