Toremifene
Title: Toremifene
CAS Registry Number: 89778-26-7
CAS Name: 2-[4-[(1Z)-4-Chloro-1,2-diphenyl-1-butenyl]phenoxy]-N,N-dimethylethanamine
Additional Names: (Z)-4-chloro-1,2-diphenyl-1-[4-[2-(N,N-dimethylamino)ethoxy]phenyl]-1-butene
Molecular Formula: C26H28ClNO
Molecular Weight: 405.96
Percent Composition: C 76.92%, H 6.95%, Cl 8.73%, N 3.45%, O 3.94%
Literature References: Nonsteroidal antiestrogen structurally similar to tamoxifen, q.v. Prepn: R. J. Toivola et al., EP 95875; eidem, US 4696949 (1983, 1987 both to Farmos). Pharmacology: S. Kallio et al., Cancer Chemother. Pharmacol. 17, 103 (1986). Antitumor effects in vitro and in vivo: L. Kangas et al., ibid. 109. HPLC determn in plasma: W. M. Holleran et al., Anal. Lett. 20, 871 (1987). Clinical evaluation in high-grade prostatic intraepithelial neoplasia: M. S. Steiner, C. R. Pound, Clin. Prostate Cancer 2, 24 (2003). Review of pharmacology and clinical efficacy in advanced breast cancer: L. R. Wiseman, K. L. Goa, Drugs 54, 141-160 (1997); in postmenopausal breast cancer: J. U. Mäenpää, S.-L. Ala-Fossi, Drugs Aging 11, 261-270 (1997).
Properties: mp 108-110°.
Melting point: mp 108-110°
 
Derivative Type: Citrate
CAS Registry Number: 89778-27-8
Manufacturers' Codes: FC-1157a
Trademarks: Acapodene (GTx); Fareston (Farmos)
Molecular Formula: C26H28ClNO.C6H8O7
Molecular Weight: 598.08
Percent Composition: C 64.26%, H 6.07%, Cl 5.93%, N 2.34%, O 21.40%
Properties: mp 160-162°.
Melting point: mp 160-162°
 
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic (Hormonal); Antiestrogens; Selective Estrogen Receptor Modulator (SERM).

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