Triacetin
Title: Triacetin
CAS Registry Number: 102-76-1
CAS Name: 1,2,3-Propanetriol triacetate
Additional Names: glyceryl triacetate; triacetyl glycerine
Trademarks: Enzactin (Ayerst); Fungacetin (Harvey)
Molecular Formula: C9H14O6
Molecular Weight: 218.20
Percent Composition: C 49.54%, H 6.47%, O 43.99%
Line Formula: C3H5(OCOCH3)3
Literature References: Prepd by acetylation of glycerol: Dunbar, Bolstad, J. Org. Chem. 21, 1041 (1956); by reaction of oxygen with a liquid phase mixture of allyl acetate and acetic acid using a bromide as catalyst: Keith, US 2911437 (1959 to Sinclair Refining). As an antifungal: GB 845029 (1960 to Wisc. Alumni Res. Found.). Acute toxicity: A. Wretlind, Acta Physiol. Scand. 40, 338 (1957).
Properties: Colorless, somewhat oily liquid having a slight, fatty odor and a bitter taste. d425 1.1562, d420 1.1596, d2020 1.163. mp -78°. bp 258-260°, bp40 172°. nD20 1.4307. Sol in 14 parts water. Miscible with alcohol, ether, chloroform. Slightly sol in carbon disulfide. LD50 i.v. in mice: 1600 ±81 mg/kg (Wretlind).
Melting point: mp -78°
Boiling point: bp 258-260°; bp40 172°
Index of refraction: nD20 1.4307
Density: d425 1.1562; d420 1.1596; d2020 1.163
Toxicity data: LD50 i.v. in mice: 1600 ±81 mg/kg (Wretlind)
Use: As fixative in perfumery; solvent in manuf celluloid, photographic films. Technical triacetin (a mixture of mono-, di-, and small quantities of triacetin) as a solvent for basic dyes, particularly indulines, and tannin in dyeing.
Therap-Cat: Antifungal (topical).
Keywords: Antifungal (Synthetic).

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