Trithiozine
Title: Trithiozine
CAS Registry Number: 35619-65-9
CAS Name: 4-[Thioxo(3,4,5-trimethoxyphenyl)methyl]morpholine
Additional Names: 4-(3,4,5-trimethoxythiobenzoyl)morpholine; sulmetozine (rescinded INN); tritiozine
Manufacturers' Codes: ISF-2001
Trademarks: Tresanil (ISF)
Molecular Formula: C14H19NO4S
Molecular Weight: 297.37
Percent Composition: C 56.55%, H 6.44%, N 4.71%, O 21.52%, S 10.78%
Literature References: Non-anticholinergic gastric secretion inhibitor. Prepn: G. Pifferi, DE 2102246; idem, US 3862138 (1972, 1975 both to ISF). Synthesis and pharmacology: G. Pifferi et al., Chim. Ther. 8, 462 (1973). HPLC determn in plasma and urine: T. Crolla et al., J. Chromatogr. 222, 257 (1981). Clinical studies: M. Elakovic et al., J. Int. Med. Res. 8, 347 (1980); U. Marini et al., Clin. Ter. 92, 399 (1980). Evaluation of gastric acid suppression: K. Gibinski, Curr. Med. Res. Opin. 7, 516 (1981).
Properties: Pale yellow solid from ethanol, mp 141-143°. LD50 i.p. in mice: 2000 mg/kg (Pifferi, 1973).
Melting point: mp 141-143°
Toxicity data: LD50 i.p. in mice: 2000 mg/kg (Pifferi, 1973)
Therap-Cat: Antisecretory (gastric).
Keywords: Antiulcerative.

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