Tymazoline
Title: Tymazoline
CAS Registry Number: 24243-97-8
CAS Name: 4,5-Dihydro-2-[[5-methyl-2-(1-methylethyl)phenoxy]methyl]-1H-imidazole
Additional Names: 2-[(thymyloxy)methyl]-2-imidazoline; 2-(thymyloxymethyl)glyoxalidine; 2-[(p-mentha-1,3,5-trien-2-yloxy)methyl]-2-imidazoline
Molecular Formula: C14H20N2O
Molecular Weight: 232.32
Percent Composition: C 72.38%, H 8.68%, N 12.06%, O 6.89%
Literature References: Prepd from an alkyl thymyloxyacetimidate and ethylenediamine: Sonn, US 2149473 (1939 to Ciba); Djerassi, Scholz, J. Am. Chem. Soc. 69, 1688 (1947). Pharmacology: Pham-Huu-Chanh et al., Therapie 24, 797 (1969).
 
Derivative Type: Hydrochloride
Trademarks: Pernazene (Synthelabo)
Molecular Formula: C14H20N2O.HCl
Molecular Weight: 268.78
Percent Composition: C 62.56%, H 7.88%, N 10.42%, O 5.95%, Cl 13.19%
Properties: Crystals, mp 215-217° (Sonn); from water or methyl ethyl ketone + ethanol, mp 223.5-225° (Djerassi, Scholz).
Melting point: mp 215-217° (Sonn); mp 223.5-225° (Djerassi, Scholz)
 
Therap-Cat: Nasal decongestant.
Keywords: a-Adrenergic Agonist; Decongestant.

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