Unoprostone
Title: Unoprostone
CAS Registry Number: 120373-36-6
CAS Name: (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-(3-oxodecyl)cyclopentyl]-5-heptenoic acid
Additional Names: 13,14-dihydro-15-keto-20-ethyl-PGF2a
Molecular Formula: C22H38O5
Molecular Weight: 382.53
Percent Composition: C 69.08%, H 10.01%, O 20.91%
Literature References: Prepn: R. Ueno et al., EP 289349; eidem, US 5221763 (1988, 1993 both to Ueno). Pharmacological characterization: Y. Goh, J. Kishino, Jpn. J. Ophthalmol. 38, 236 (1994). Mechanism of action study: M. Sakurai et al., ibid. 37, 252 (1993). Comparative clinical trial in glaucoma and ocular hypertension: J.-P. Nordmann et al., Am. J. Ophthalmol. 133, 1 (2002).
 
Derivative Type: Isopropyl ester
CAS Registry Number: 120373-24-2
Manufacturers' Codes: UF-021
Trademarks: Rescula (Novartis)
Molecular Formula: C25H44O5
Molecular Weight: 424.61
Percent Composition: C 70.72%, H 10.44%, O 18.84%
 
Therap-Cat: Antiglaucoma; in treatment of ocular hypertension.
Keywords: Antiglaucoma; Prostaglandin/Prostaglandin Analog.

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