Urea Stibamine
Title: Urea Stibamine
CAS Registry Number: 1340-35-8
Additional Names: Carbostibamide
Literature References: Pentavalent antimonial. Therapeutic efficacy in kala-azar: U. N. Brahmachari, Indian J. Med. Res. 10, 492 (1922). Prepn and proposed structure as NH2CONHC6H4SbO(OH)ONH4: U. N. Brahmachari, J. Das, ibid. 12, 423 (1924). Shown to be a mixture of products with sym-diphenylcarbamido-4,4ยข-distibonic acid as the active principal: W. H. Gray et al., Proc. Roy. Soc. B108, 54 (1931). Description of development: R. C. Guha et al., Nature 151, 108 (1943); W. Peters, Indian J. Med. Res. 73 Suppl., 1 (1981). Improved prepn, characterization and activity: S. B. Mahato et al., Biochem. Med. Metab. Biol. 38, 47 (1987).
Properties: Sol in water. Partially sol in alc, ether.
Therap-Cat: Antiprotozoal (Leishmania).
Keywords: Anthelmintic (Nematodes); Anthelmintic (Schistosoma); Antiprotozoal (Leishmania).

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