Zenarestat
Title: Zenarestat
CAS Registry Number: 112733-06-9
CAS Name: 3-[(4-Bromo-2-fluorophenyl)methyl]-7-chloro-3,4-dihydro-2,4-dioxo-1(2H)-quinazolineacetic acid
Additional Names: 3-(4-bromo-2-fluorobenzyl)-7-chloro-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-1-acetic acid
Manufacturers' Codes: FK-366; FR-74366
Molecular Formula: C17H11BrClFN2O4
Molecular Weight: 441.64
Percent Composition: C 46.23%, H 2.51%, Br 18.09%, Cl 8.03%, F 4.30%, N 6.34%, O 14.49%
Literature References: Aldose reductase inhibitor. Prepn: M. Hashimoto et al., EP 218999; eidem, US 4734419 (1987, 1988 both to Fujisawa). Inhibition kinetics and effect on sorbitol accumulation: S. Ao et al., Metabolism 40, 77 (1991). Pharmacokinetics and metabolism in diabetic rats: Y. Tanaka et al., Drug Metab. Dispos. 21, 677 (1993). Clinical pharmacology: M. Kanamaru et al., J. Clin. Pharmacol. 33, 1122 (1993).
Properties: Crystals from ethanol + water, mp 223-224°.
Melting point: mp 223-224°
Therap-Cat: In treatment of diabetic neuropathy and cataract.
Keywords: Aldose Reductase Inhibitor.
 
 
Status: This monograph has been retired and is no longer subject to revision or update.

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