Title: Aceglatone
CAS Registry Number: 642-83-1
CAS Name: D-Glucaric acid di-g-lactone diacetate
Additional Names: 2,5-di-O-acetyl-D-glucaro-1,4:6,3-dilactone; 2,5-di-O-acetyl-D-glucosaccharo-1,4:6,3-dilactone
Trademarks: Glucaron (Chugai)
Molecular Formula: C10H10O8
Molecular Weight: 258.18
Percent Composition: C 46.52%, H 3.90%, O 49.58%
Literature References: Prepn and structure: Hirasaka, Umemoto, Chem. Pharm. Bull. 13, 325 (1965), C.A. 63, 3024h (1965); Ishidate et al., JP 67 14956 (1967 to Tokyo Biochem. Res. Com.), C.A. 68, 78558m (1968). Pharmacological studies: Iida et al., Jpn. J. Pharmacol. 15, 88 (1965), C.A. 63, 5961g (1965).
Properties: White, odorless and tasteless crystalline powder, mp 185-186° (Hirasaka). Sol in dimethylformamide, sparingly sol in acetone, slightly sol in dioxane, methanol and ethanol. Practically insol in water.
Melting point: mp 185-186° (Hirasaka)
Therap-Cat: Antineoplastic.
Status: This monograph has been retired and is no longer subject to revision or update.

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