Title: Activin
Literature References: Polypeptide hormone, identified in ovarian follicular fluid, which selectively stimulates secretion of FSH, q.v. Dimer composed of b subunits of inhibin, q.v. (either bA or bB), mol wt 24,000 daltons. Isolation and characterization of the heterodimer, activin AB: N. Ling et al., Nature 321, 779 (1986); of the homodimer, activin A: W. Vale et al., ibid. 776; N. Ling et al., Biochem. Biophys. Res. Commun. 138, 1129 (1986). Comparison of FSH stimulation with gonadotropin releasing hormone (LH-RH, q.v.): R. H. Schwall et al., ibid. 151, 1099 (1988). Approach to nonradiometric assays: R. H. Schwall et al., Prog. Clin. Biol. Res. 285, 205 (1988). Brief review of chemical properties and biological activity: S.-Y. Ying, Proc. Soc. Exp. Biol. Med. 186, 253-264 (1987). Review: S. A. Pangas, T. K. Woodruff, Trends Endocrinol. Metab. 11, 309-314 (2000).

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