Bacitracin Methylenedisalicylate
Title: Bacitracin Methylenedisalicylate
CAS Registry Number: 1405-88-5
CAS Name: Bacitracin methylenebis[2-hydroxybenzoate] (salt)
Additional Names: bacitracin methylenedisalicylic acid
Trademarks: BMD (Alpharma); Solu-Tracin (Alpharma)
Literature References: Prepn: Baron, US 2774712 (1956 to S. B. Penick & Co.). LC determn in animal feed: G. K. Webster, J. AOAC Int. 80, 732 (1997). Efficacy as growth promotant: A. L. Izat et al., Poult. Sci. 69, 1787 (1990); in combination with anticoccidial agents: H. D. Chapman et al., Avian Pathol. 27, 498 (1998).
Properties: White to grayish-brown powder. Slightly disagreeable odor. Somewhat less bitter than bacitracin. uv max (dil acetic acid): 318 nm, min: 280 nm. Solubility in water about 50 mg/ml. pH of satd aq soln 3.5 to 5.0. Sol in pyridine, ethanol, less sol to insol in acetone, ether, chloroform, pentane, benzene. Sol in dil aq alkali at pH 6 and higher, increasingly insol at pH 6 to 3.
Absorption maximum: uv max (dil acetic acid): 318 nm, min: 280 nm
Derivative Type: Sodium salt
Properties: Creamy-white powder. Sol in water. pH 2% aq soln 9.5.
Therap-Cat-Vet: Animal growth promotant; antibacterial.

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