Benzalkonium Chloride
Title: Benzalkonium Chloride
CAS Registry Number: 8001-54-5
CAS Name: Alkylbenzyldimethyl quaternary ammonium compounds chlorides
Additional Names: alkyldimethyl(phenylmethyl)ammonium chloride
Trademarks: Baktonium (Bode); Benirol (Linobion); Bradosol (Novartis); Callusolve (Dermal); Capitol (Dermal); Laudamonium (Henkel); Osvan (Takeda); Pharmatex (Innoth┬×a); Roccal (Sanofi-Synthelabo); Sagrotan (Schîke & Mayr); Zephiran (Sanofi-Synthelabo); Zephirol (Bayer)
Literature References: A mixture of alkyldimethylbenzylammonium chlorides; three major homologues consist of C12, C14 and C16 straight chain alkyls. Prepn and biological activity: R. A. Cutler et al., Proc. Annu. Meet. Chem. Spec. Manuf. Assoc. 1966, 102. Acute toxicity data: L. M. Cummins, E. T. Kimura, Toxicol. Appl. Pharmacol. 20, 89 (1971). Capillary electrophoretic determn in formulations: M. Jimidar et al., Biomed. Chromatogr. 12, 128 (1998); MS determn on skin: S. Kawakami et al., Analyst 123, 489 (1998). Efficacy as disinfecting wound irrigant: B. B. Tarbox et al., Clin. Orthop. Relat. Res. 1998, 255. Use as disinfectant against viruses: A. Wood, D. Payne, J. Hosp. Infect. 38, 283 (1998). Brief review: A. C. S. Parr et al., Spec. Chem. 16, 157-160 (1996).
Properties: White or yellowish-white, amorphous powder or gelatinous pieces. Very sol in water, alcohol, acetone; slightly sol in benzene. Almost insol in ether. The aq soln is slightly alkaline to litmus and foams strongly when shaken. LD50 orally in rats: 400 mg/kg (Cummins, Kimura).
Toxicity data: LD50 orally in rats: 400 mg/kg (Cummins, Kimura)
Use: Cationic surface active agent and germicide. Pharmaceutic aid (preservative). Algicide.
Therap-Cat: Antiseptic, disinfectant.
Therap-Cat-Vet: Antiseptic for skin preoperatively or for wounds, burns, etc. Udder wash.
Keywords: Antiseptic/Disinfectant; Quaternary Ammonium Compounds.

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