Title: Dopamine
CAS Registry Number: 51-61-6
CAS Name: 4-(2-Aminoethyl)-1,2-benzenediol
Additional Names: 4-(2-aminoethyl)pyrocatechol; 3-hydroxytyramine; 3,4-dihydroxyphenethylamine; a-(3,4-dihydroxyphenyl)-b-aminoethane
Molecular Formula: C8H11NO2
Molecular Weight: 153.18
Percent Composition: C 62.73%, H 7.24%, N 9.14%, O 20.89%
Literature References: Endogenous catecholamine with a and b-adrenergic activity. Isoln from Hermidium alipes (S. Watson) Nyctaginaceae: Buelow, Gisvold, J. Am. Pharm. Assoc. 33, 270 (1944). Prepn from aminotyramine: Waser, Sommer, Helv. Chim. Acta 6, 61 (1923). From homoveratrylamine: Schöpf, Bayeler, Ann. 513, 196 (1934); Hahn, Stiehl, Ber. 69, 2640 (1936). Comprehensive description of the hydrochloride: J. E. Carter et al., Anal. Profiles Drug Subs. 11, 257-272 (1982). Review of pharmacology and clinical efficacy in oliguria: J. F. Dasta, M. G. Kirby, Pharmacotherapy 6, 304 (1986).
Properties: Free base, stout prisms, highly sensitive to oxygen; discolors quickly.
Derivative Type: Hydrochloride
CAS Registry Number: 62-31-7
Manufacturers' Codes: ASL-279
Trademarks: Cardiosteril (Fresenius); Dopastat (Parke-Davis); Dynatra (Simes); Inovan (Kyowa); Inotropin (Bago)
Molecular Formula: C8H11NO2.HCl
Molecular Weight: 189.64
Percent Composition: C 50.67%, H 6.38%, N 7.39%, O 16.87%, Cl 18.69%
Properties: Rosettes of needles from water, dec 241°; may be recrystallized from methanol + ether. Freely sol in water; sol in methanol, in hot 95% ethanol; in aq solns of alkali hydroxides. Practically insol in ether, petr ether, chloroform, benzene, toluene.
Derivative Type: Hydrobromide
Molecular Formula: C8H11NO2.HBr
Molecular Weight: 234.09
Percent Composition: C 41.05%, H 5.17%, N 5.98%, O 13.67%, Br 34.13%
Properties: Crystals, dec 210-214°.
Therap-Cat: Cardiotonic; antihypotensive.
Keywords: Antihypotensive; Cardiotonic.

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