Title: Modafinil
CAS Registry Number: 68693-11-8
CAS Name: 2-[(Diphenylmethyl)sulfinyl]acetamide
Additional Names: 2-(benzhydrylsulfinyl)acetamide
Manufacturers' Codes: CRL-40476
Trademarks: Attenace (Cephalon); Provigil (Cephalon)
Molecular Formula: C15H15NO2S
Molecular Weight: 273.35
Percent Composition: C 65.91%, H 5.53%, N 5.12%, O 11.71%, S 11.73%
Literature References: a1-Adrenergic agonist. Prepn: L. Lafon, DE 2809625; eidem, US 4177290 (1978, 1979 both to Lab. Lafon). Effects on vigilance: F. Goldenberg, J. S. Weil, Sleep (Stuttgart) 8, 343 (1988); on normal sleep: B. Saletu et al., Int. J. Clin. Pharmacol. Res. 9, 183 (1989). Clinical evaluation in hypersomnia and narcolepsy: H. Bastuji, M. Jouvet, Prog. Neuro-Psychopharmacol. Biol. Psychiatry 12, 695 (1988); in adult attention-deficit/hyperactivity disorder: D. C. Turner et al., Biol. Psychiatry 55, 1031 (2004).
Properties: Crystals from methanol, mp 164-166°. Sparingly to slightly sol in methanol, acetone. Practically insol in water, cyclohexane.
Melting point: mp 164-166°
NOTE: This is a controlled substance (stimulant): 21 CFR, 1308.14.
Therap-Cat: CNS Stimulant.
Keywords: a-Adrenergic Agonist; CNS Stimulant.

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