Osaterone
Title: Osaterone
CAS Registry Number: 105149-04-0
CAS Name: 6-Chloro-17-hydroxy-2-oxapregna-4,6-diene-3,20-dione
Molecular Formula: C20H25ClO4
Molecular Weight: 364.86
Percent Composition: C 65.84%, H 6.91%, Cl 9.72%, O 17.54%
Literature References: Androgen receptor antagonist. Prepn: K. Shibata et al., EP 193871; eidem, US 4785103 (1986, 1988 both to Teikoku Hormone); K. Shibata et al., Chem. Pharm. Bull. 40, 935 (1992). Pharmacology: M. Murakoshi et al., Acta Pathol. Jpn. 42, 151 (1992); T. Ichikawa et al., Endocr. J. 40, 425 (1993); M. Murakoshi et al., ibid. 479.
Properties: Colorless prisms from acetone/hexane, mp 218-221°.
Melting point: mp 218-221°
 
Derivative Type: Acetate ester
CAS Registry Number: 105149-00-6
Additional Names: 2-Oxachlormadinone acetate
Manufacturers' Codes: TZP-4238
Molecular Formula: C22H27ClO5
Molecular Weight: 406.90
Percent Composition: C 64.94%, H 6.69%, Cl 8.71%, O 19.66%
Properties: Colorless prisms from acetone/hexane, mp 253-255°.
Melting point: mp 253-255°
 
Therap-Cat: Treatment of benign prostatic hypertrophy; antiandrogen.
Keywords: Antiandrogen; Antiprostatic Hypertrophy.

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