Phloretin
Title: Phloretin
CAS Registry Number: 60-82-2
CAS Name: 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone
Additional Names: 2¢,4¢,6¢-trihydroxy-3-(p-hydroxyphenyl)propiophenone; b-(p-hydroxyphenyl)phloropropiophenone; b-(p-hydroxyphenyl)-2,4,6-trihydroxypropiophenone
Molecular Formula: C15H14O5
Molecular Weight: 274.27
Percent Composition: C 65.69%, H 5.14%, O 29.17%
Literature References: The aglucon of phlorizin, q.v. From root bark of apple trees: Rochleder, J. Prakt. Chem. 98, 205 (1866). Structure: Seshadri, Annu. Rev. Biochem. 20, 495 (1951). Synthesis: Fischer, Nouri, Ber. 50, 611 (1917); Rosenmund, Rosenmund, ibid. 61B, 2608 (1928); Shinoda et al., J. Pharm. Soc. Jpn. 49, 797 (1929); Johnston, US 2789995 (1957 to Union Carbide).
Properties: Needles from dil alcohol, dec 262°. Absorption spectrum: Lambrechts, Arch. Int. Physiol. 44, Suppl., 1-39 (1937). Freely sol in alc, methanol, acetone; sol in alkalies in hot glacial acetic acid; very sparingly sol in benzene, chloroform. Practically insol in water, ether, the soly being increased by addition of alcohol.

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