Rose Bengal
Title: Rose Bengal
CAS Registry Number: 632-68-8
CAS Name: 4,5,6,7-Tetrachloro-3¢,6¢-dihydroxy-2¢,4¢,5¢,7¢-tetraiodospiro[isobenzofuran-1(3H),9¢-[9H]xanthen]-3-one dipotassium salt
Additional Names: 4,5,6,7-tetrachloro-2¢,4¢,5¢,7¢-tetraiodofluorescein dipotassium salt; C.I. Acid Red 94; Rose Bengale B; C.I. 45440
Molecular Formula: C20H2Cl4I4K2O5
Molecular Weight: 1049.85
Percent Composition: C 22.88%, H 0.19%, Cl 13.51%, I 48.35%, K 7.45%, O 7.62%
Literature References: Discovered by Gnehm 1882; tetraiodinate of 4,5,6,7-tetrachlorofluorescein (from resorcinol and tetrachlorophthalic anhydride) converted to potassium salt: Colour Index vol. 4 (3rd ed., 1971) 4428. Labeling with 131I: Liebster, Andrysek, Nature 184, 913 (1959). See also: H. J. Conn's Biological Stains, R. D. Lillie, Ed., (Williams & Wilkins, Baltimore, 9th ed., 1977) p 350. Diagnostic use in hepatic function: K. S. Nijran, D. C. Barber, Phys. Med. Biol. 31, 563 (1986).
Properties: Bright bluish pink. Soluble in water (bluish red without fluorescence); brown soln in concd H2SO4, on dilution gives flesh pink ppt.
Derivative Type: Disodium salt
CAS Registry Number: 632-69-9
Additional Names: Rose Bengal Extra
Molecular Formula: C20H2Cl4I4Na2O5
Molecular Weight: 1017.64
Percent Composition: C 23.61%, H 0.20%, Cl 13.94%, I 49.88%, Na 4.52%, O 7.86%
Derivative Type: 131I-Labeled disodium salt
CAS Registry Number: 50291-21-9
Additional Names: Sodium rose bengal I 131; rose bengal sodium I 131
Trademarks: Robenogatope I-131 (BMS)
NOTE: C.I. Acid Red 94 and C.I. 45440 also used for disodium salt.
Use: As a dye, biological stain; in coloring straw, wood chips, and inks; for coloring edible products and cosmetics.
Therap-Cat: Diagnostic aid (corneal trauma indicator). Sodium Rose Bengal I 131 as diagnostic aid (hepatic function).
Keywords: Diagnostic Aid.

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