Title: Sulfapyrazine
CAS Registry Number: 116-44-9
CAS Name: 4-Amino-N-(pyrazinyl)benzenesulfonamide
Additional Names: N1-2-pyrazinylsulfanilamide; 2-sulfanilamidopyrazine
Molecular Formula: C10H10N4O2S
Molecular Weight: 250.28
Percent Composition: C 47.99%, H 4.03%, N 22.39%, O 12.79%, S 12.81%
Literature References: Prepd by reacting acetylsulfanilyl chloride with 2-aminopyrazine in pyridine, followed by hydrolysis and neutralization: Ellingson, US 2420703 (1947). Biological properties: Ghione et al., Chemotherapia 6, 344 (1962).
Properties: Crystals, dec 250-254°. Very slightly sol in alc; slightly sol in acetone. Sol in aq solns of sodium, potassium, and barium hydroxides, in ammonia water, and in dil and concd mineral acid solns. Practically insol in water (5 mg/100 ml at 25°, and 5.2 mg/100 ml at 37°).
Derivative Type: Sodium salt monohydrate
Molecular Formula: C10H9N4NaO2S.H2O
Molecular Weight: 290.27
Percent Composition: C 41.38%, H 3.82%, N 19.30%, Na 7.92%, O 16.54%, S 11.05%
Properties: Bitter powder. Freely soluble in water (1 g/3.33 ml at 25°). Alkaline to litmus. pH of 10% aq soln 9.1. Very sol in acetone, slightly sol in alc. Insol in ether, chloroform. Aq solns of sulfapyrazine sodium may absorb carbon dioxide which causes precipitation of sulfapyrazine.
Therap-Cat: Antibacterial.
Therap-Cat-Vet: Antibacterial.
Keywords: Antibacterial (Synthetic); Sulfonamides.

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