Trimethobenzamide
Title: Trimethobenzamide
CAS Registry Number: 138-56-7
CAS Name: N-[(2-Dimethylaminoethoxy)benzyl]-3,4,5-trimethoxybenzamide
Additional Names: 4-(2-dimethylaminoethoxy)-N-(3,4,5-trimethoxybenzoyl)benzylamine
Molecular Formula: C21H28N2O5
Molecular Weight: 388.46
Percent Composition: C 64.93%, H 7.27%, N 7.21%, O 20.59%
Literature References: Prepn: Goldberg, Teitel, US 2879293 (1959 to Hoffmann-La Roche). Pharmacology: K. W. Blessel et al., Anal. Profiles Drug Subs. 2, 551-570 (1973).
 
Derivative Type: Hydrochloride
CAS Registry Number: 554-92-7
Manufacturers' Codes: Ro-2-9578
Trademarks: Anaus (Molteni); Tigan (SKB); Xametina (Zambeletti)
Molecular Formula: C21H28N2O5.HCl
Molecular Weight: 424.92
Percent Composition: C 59.36%, H 6.88%, N 6.59%, O 18.83%, Cl 8.34%
Properties: Crystals, mp 187.5-190°. Freely sol in water (approx soly at 25° >50%). A 5% aq soln is stable to autoclaving at 120° for 20 min at pH 3-7.
Melting point: mp 187.5-190°
 
Therap-Cat: Antiemetic.
Keywords: Antiemetic.

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