Agomelatine
Title: Agomelatine
CAS Registry Number: 138112-76-2
CAS Name: N-[2-(7-Methoxy-1-naphthalenyl)ethyl]acetamide
Manufacturers' Codes: S-20098
Trademarks: Valdoxan (Biopharma)
Molecular Formula: C15H17NO2
Molecular Weight: 243.30
Percent Composition: C 74.05%, H 7.04%, N 5.76%, O 13.15%
Literature References: Melatoninergic agonist and selective serotonin 5-HT2B and 5-HT2C receptor antagonist; metabolically stable analogue of melatonin, q.v. Prepn: J. Andrieux et al., EP 447285; eidem, US 5225442 (1991, 1993 both to Adir); and structure-activity studies: S. Yous et al., J. Med. Chem. 35, 1484 (1992); P. Depreux et al., ibid. 37, 3231 (1994). Mechanism of action: M. J. Millan et al., J. Pharmacol. Exp. Ther. 306, 954 (2003). Clinical evaluation in major depressive disorder: H. Lôo et al., Int. Clin. Psychopharmacol. 17, 239 (2002); S. H. Kennedy, R. Emsley, Eur. Neuropsychopharmacol. 16, 93 (2006).
Properties: Crystals from toluene + hexane, 2:1, mp 109-110°.
Melting point: mp 109-110°
Therap-Cat: Antidepressant.
Keywords: Serotonin Receptor Antagonist; Antidepressant.

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