Chlordiazepoxide
Title: Chlordiazepoxide
CAS Registry Number: 58-25-3
CAS Name: 7-Chloro-N-methyl-5-phenyl-3H-1,4-benzodiazepin-2-amine 4-oxide
Additional Names: 7-chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepine 4-oxide; methaminodiazepoxide; clopoxide
Trademarks: Helogaphen (Spitzner); Libritabs (Roche); Multum (Chephasaar); Risolid (Dumex); Silibrin (Silesia); Tropium (DDSA)
Molecular Formula: C16H14ClN3O
Molecular Weight: 299.75
Percent Composition: C 64.11%, H 4.71%, Cl 11.83%, N 14.02%, O 5.34%
Literature References: Prototype of the benzodiazepine anxiolytics. Prepn: Sternbach, US 2893992 (1959 to Hoffmann-La Roche); Sternbach, Reeder, J. Org. Chem. 26, 1111 (1961). Comprehensive description: A. MacDonald et al., Anal. Profiles Drug Subs. 1, 15-51 (1972). Review of pharmacokinetics: D. J. Greenblatt et al., Clin. Pharmacokinet. 3, 381-394 (1978); of pharmacology and effect on cognitive function: J. B. Murray, Genet. Psychol. Monogr. 109 (2), 167-197 (1984). Clinical trial in alcohol withdrawal: A. K. Burroughs et al., Alcohol Alcohol. 20, 263 (1985).
Properties: Light yellow plates from ethanol, mp 236-236.5°. pK 4.8.
Melting point: mp 236-236.5°
pKa: pK 4.8
 
Derivative Type: Hydrochloride
CAS Registry Number: 438-41-5
Trademarks: Ansiacal (Beolet); A-Poxide (Abbott); Balance (Yamanouchi); Benzodiapin (Lisapharma); Cebrum (SIFA); Corax (Empire); Disarim (Bial); Elenium (Polfa); Equibral (Ravizza); Labican (Boniscontro); Lentotran (Farmopatria); Librium (Roche); O.C.M. (Gobbi-Novag); Psichial (Lang); Psicoterina (Francia); Reliberan (Geymonat); Seren Vita (Synthelabo); SK-Lygen (SKB); Viansin (Farmocosmici)
Molecular Formula: C16H14ClN3O.HCl
Molecular Weight: 336.22
Percent Composition: C 57.16%, H 4.50%, Cl 21.09%, N 12.50%, O 4.76%
Properties: Crystals from methanol, mp 213°. Sol in water.
Melting point: mp 213°
 
NOTE: This is a controlled substance (depressant): 21 CFR, 1308.14.
Therap-Cat: Anxiolytic.
Therap-Cat-Vet: Tranquilizer.
Keywords: Anxiolytic; Benzodiazepine Derivatives.

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