Difemerine
Title: Difemerine
CAS Registry Number: 80387-96-8
CAS Name: a-Hydroxy-a-phenylbenzeneacetic acid 2-(dimethylamino)-2-methylpropyl ester
Additional Names: 2-(dimethylamino)-1,1-dimethylethyl benzilate
Molecular Formula: C20H25NO3
Molecular Weight: 327.42
Percent Composition: C 73.37%, H 7.70%, N 4.28%, O 14.66%
Literature References: Anticholinergic. Prepn: S. G. Kuznetsov, A. G. El'tsov, Zh. Obshch. Khim. 32, 511 (1962), C.A. 58, 470d (1963); C. Hoffmann, FR M3406 (1965 to Labs. U.P.S.A.), C.A. 63, 13163ab (1965). Toxicity: S. N. Golikov, S. G. Kuznetsov, C.A. 61, 8790b (1964). Comparison of side effects with those of atropine: L. Moser, P. V. Lundt, Med. Welt 31, 1795 (1980). Crystal structure: A. Carpy et al., Acta Crystallogr. B35, 882 (1979).
Properties: Solid, mp 78-78.3°.
Melting point: mp 78-78.3°
 
Derivative Type: Hydrochloride
CAS Registry Number: 70280-88-5
Trademarks: Luostyl (UPSA)
Molecular Formula: C20H25NO3.HCl
Molecular Weight: 363.88
Percent Composition: C 66.01%, H 7.20%, N 3.85%, O 13.19%, Cl 9.74%
Properties: Crystals from isopropanol, mp 182°.
Melting point: mp 182°
 
Therap-Cat: Antispasmodic.
Keywords: Antispasmodic; Antimuscarinic.

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