Fluocinonide
Title: Fluocinonide
CAS Registry Number: 356-12-7
CAS Name: (6a,11b,16a)-21-(Acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
Additional Names: 6a,9-difluoro-11b,16a,17,21-tetrahydroxypregna-1,4-diene-3,20-dione, cyclic 16,17-acetal with acetone, 21-acetate; 21-acetoxy-6a,9a-difluoro-11b-hydroxy-16a,17a-isopropylidenedioxy-1,4-pregnadiene-3,20-dione; 16a,17a-isopropylidene-6a-fluorotriamcinolone 21-acetate; fluocinolide (obsolete); fluocinolide acetate (obsolete); fluocinolone acetonide acetate
Trademarks: Biscosal (Ohta); Dermaplus (Ripari-Gero); Lidex (Syntex); Metosyn (Zeneca); Synalate (rescinded) (Syntex); Straderm (ITA); Topsym (Grñenthal); Topsymin (Grñenthal); Topsyne (Cassenne); Topsyn (Syntex)
Molecular Formula: C26H32F2O7
Molecular Weight: 494.52
Percent Composition: C 63.15%, H 6.52%, F 7.68%, O 22.65%
Literature References: Prepn: GB 916996 (1963 to Olin Mathieson), C.A. 59, 1716b (1963); H. J. Ringold, G. Rosenkranz, US 3124571; H. J. Ringold et al., US 3126375 (both 1964 to Syntex); J. Fried, US 3197469 (1965 to Pharm. Res. Prod.). NMR: A. D. Cross, P. W. Landis, J. Am. Chem. Soc. 86, 4005 (1964).
Properties: Crystals from methanol. mp 308-311°. [a]D +83° (chloroform). uv max: 237 nm (log e 4.18).
Melting point: mp 308-311°
Optical Rotation: [a]D +83° (chloroform)
Absorption maximum: uv max: 237 nm (log e 4.18)
Therap-Cat: Anti-inflammatory; glucocorticoid.
Keywords: Glucocorticoid.

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