Hexamethonium
Title: Hexamethonium
CAS Registry Number: 60-26-4
CAS Name: N,N,N,N¢,N¢,N¢-Hexamethyl-1,6-hexanediaminium
Additional Names: hexamethylenebis(trimethylammonium); a,w-bis(trimethylammonium)hexane; hexathonide; hexamethone
Molecular Formula: [C12H30N2]2+
Line Formula: [(CH3)3N(CH2)6N(CH3)3]2+
Literature References: Prepn: H. J. Barber, US 2641610 (1953 to May & Baker); H. J. Barber, K. Gaimster, J. Pharm. Pharmacol. 3, 663 (1951). Ganglion blocking agent: R. Wien, D. F. J. Mason, Br. J. Pharmacol. 6, 611 (1951).
 
Derivative Type: Bromide
CAS Registry Number: 55-97-0
Manufacturers' Codes: C-6
Trademarks: Bistrium bromide (BMS); Esametina; Gangliostat; Hexameton bromide (Burroughs Wellcome); Hexanium bromide (Adrian-Marinier); Simpatoblock; Vegolysen (M & B); Vegolysin
Molecular Formula: C12H30Br2N2
Molecular Weight: 362.19
Percent Composition: C 39.79%, H 8.35%, Br 44.12%, N 7.73%
Properties: Hygroscopic crystals, mp 274-276°. Sol in water, alc. Insol in acetone, chloroform, ether. pH of 1% soln: 6.2-7.0.
Melting point: mp 274-276°
 
Derivative Type: Chloride
Trademarks: Bistrium chloride (BMS); Chloor-hexaviet; Hestrium chloride; Hexameton chloride (Burroughs Wellcome); Hexone chloride; Hiohex chloride (Keith-Victor); Methium chloride; Meton
Molecular Formula: C12H30Cl2N2
Molecular Weight: 273.29
Percent Composition: C 52.74%, H 11.06%, Cl 25.95%, N 10.25%
Properties: Hygroscopic crystals, dec 289-292°. Sol in water, alc. Practically insol in chloroform, ether. pH of 10% soln: 5.5-6.5.
 
Derivative Type: Iodide
Trademarks: Hexathide (Allen & Hanburys)
Molecular Formula: C12H30I2N2
Molecular Weight: 456.19
Percent Composition: C 31.59%, H 6.63%, I 55.64%, N 6.14%
Properties: Hygroscopic cryst powder. Sol in water. Practically insol in alc.
 
Derivative Type: Tartrate
Trademarks: Vegolysen-T (M & B)
Molecular Formula: C20H40N2O12
Molecular Weight: 500.54
Percent Composition: C 47.99%, H 8.05%, N 5.60%, O 38.36%
Properties: Hygroscopic powder, dec 186°. Sol in water. Practically insol in alc. pH of 10% soln: 3.8.
 
Therap-Cat: Antihypertensive.
Keywords: Antihypertensive; Quaternary Ammonium Compounds.

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