Iodixanol
Title: Iodixanol
CAS Registry Number: 92339-11-2
CAS Name: 5,5¢-[(2-Hydroxy-1,3-propanediyl)bis(acetylimino)]bis[N,N¢-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide]
Additional Names: 5,5¢-[(2-hydroxytrimethylene)bis(acetylimino)]bis[N,N¢-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide]; 1,3-bis(acetylamino)-N,N¢-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane
Manufacturers' Codes: 2-5410-3A
Trademarks: Visipaque (GE Healthcare)
Molecular Formula: C35H44I6N6O15
Molecular Weight: 1550.18
Percent Composition: C 27.12%, H 2.86%, I 49.12%, N 5.42%, O 15.48%
Literature References: Nonionic, dimeric x-ray contrast medium. Prepn: P. E. Hansen et al., EP 108638 (1984 to Nyegaard), C.A. 101, 151599g (1984). HPLC determn in plasma: H. Nomura et al., J. Chromatogr. 572, 333 (1991). Clinical pharmacokinetics: M. G. Svaland et al., Invest. Radiol. 27, 130 (1992). Clinical studies in cerebral arteriography: Y. Palmers et al., Eur. J. Radiol. 17, 203 (1993); in cardiac angiography: J. A. Hill et al., Am. J. Cardiol. 74, 57 (1994); in urography: R. M. Conroy et al., Clin. Radiol. 49, 337 (1994). Use as density gradient medium: T. Ford et al., Anal. Biochem. 220, 360 (1994); J. Graham et al., ibid. 367.
Properties: mp 240-250°. Soluble in water. Viscosity (37°) 11.1 mPa; osmolality 290 mOsm/kg H2O; pH 7.2-7.6 (c = 320 mgI/ml). 50% aqueous soln (w/v): viscosity 8.3 mPa; n 1.4128 ±0.0003; d 1.266 ±0.003; osmolality 200 ±5 mOsm. LD50 i.v. in mice: 21 gI/kg (Palmers).
Melting point: mp 240-250°
Index of refraction: n 1.4128 ±0.0003
Density: d 1.266 ±0.003
Toxicity data: LD50 i.v. in mice: 21 gI/kg (Palmers)
Therap-Cat: Diagnostic aid (radiopaque medium).
Keywords: Diagnostic Aid (Radiopaque Medium).

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