Isobutyl Cyanoacrylate
Title: Isobutyl Cyanoacrylate
CAS Registry Number: 1069-55-2
CAS Name: 2-Cyano-2-propenoic acid 2-methylpropyl ester
Additional Names: 2-cyanoacrylic acid isobutyl ester; bucrilate; bucrylate; IBC; IBCA
Molecular Formula: C8H11NO2
Molecular Weight: 153.18
Percent Composition: C 62.73%, H 7.24%, N 9.14%, O 20.89%
Literature References: Monomer rapidly polymerizes upon contact with fluid or tissue. Preparative method: A. E. Ardis, US 2467926 (1949 to B. F. Goodrich). Development of polymer nanoparticles as a magnetic drug carrier: A. Ibrahim et al., J. Pharm. Pharmacol. 35, 59 (1983). Clinical experience in treatment of varicocele-associated infertility by transcatheter embolization: F. H. Comhaire, M. Kunnen, Fertil. Steril. 43, 781 (1985); in treatment of arteriovenous malformations: H. V. Vinters et al., N. Engl. J. Med. 314, 477 (1986). Review of 2-cyanoacrylic ester polymers: J. T. O'Connor in Kirk-Othmer Encyclopedia of Chemical Technology vol. 1 (Wiley-Interscience, New York, 4th ed., 1991) pp 344-352; of use in treatment of bleeding gastric varices: R. Kind et al., Endoscopy 32, 512-519 (2000).
Properties: Liquid, bp 71-73°. d 0.99. nD20 1.4352. Viscosity: 2.0 cP. Flash pt: 199°F (93°C). Heat of polymerization: 66.9 kJ/mol.
Boiling point: bp 71-73°
Flash point: Flash pt: 199°F (93°C)
Index of refraction: nD20 1.4352
Density: d 0.99
 
Derivative Type: Polymer
CAS Registry Number: 26809-38-1
Additional Names: Poly(isobutyl 2-cyanoacrylate); PIBCA
Properties: LD50 i.v. in mice (mg/kg): 242 (Ibrahim).
Toxicity data: LD50 i.v. in mice (mg/kg): 242 (Ibrahim)
 
Use: Adhesive; polymer nanoparticles as pharmaceutic aid for controlled release drug delivery.
Therap-Cat: Tissue adhesive.
Keywords: Tissue Adhesive.

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