Malotilate
Title: Malotilate
CAS Registry Number: 59937-28-9
CAS Name: 1,3-Dithiol-2-ylidenepropanedioic acid bis(1-methylethyl) ester
Additional Names: diisopropyl 1,3-dithiol-2-ylidenemalonate
Manufacturers' Codes: NKK-105
Trademarks: Hepation (Nippon Chemiphar); Kantec (Daiichi)
Molecular Formula: C12H16O4S2
Molecular Weight: 288.38
Percent Composition: C 49.98%, H 5.59%, O 22.19%, S 22.24%
Literature References: Prepn from diisopropyl malonate: K. Taninaka et al., DE 2545569; eidem, US 4035387 (1976, 1977 both to Nihon Nohyaku); from the corresponding ketene mercaptide: H. Matsui et al., US 4327223 (1982 to Nihon Nohyaku). Effect on CCl4-induced liver injury in rats: Y. Imaizumi et al., Jpn. J. Pharmacol. 31, 15 (1981). Enhancement of rat liver protein synthesis: eidem, ibid. 32, 369 (1982). Pharmacokinetics and pharmacodynamics: M. Buhrer et al., Eur. J. Clin. Pharmacol. 30, 407 (1986). Clinical evaluation in liver cirrhosis: S. Takase et al., Gastroenterol. Jpn. 23, 639 (1988).
Properties: Pale yellow crystals, mp 60.5°. Sol in benzene, cyclohexane, n-hexane, ether.
Melting point: mp 60.5°
Therap-Cat: Hepatoprotectant.
Keywords: Hepatoprotectant.

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