Metharbital
Title: Metharbital
CAS Registry Number: 50-11-3
CAS Name: 5,5-Diethyl-1-methyl-2,4,6(1H,3H,5H)-pyrimidinetrione
Additional Names: 5,5-diethyl-1-methylbarbituric acid
Trademarks: Gemonil (Abbott)
Molecular Formula: C9H14N2O3
Molecular Weight: 198.22
Percent Composition: C 54.53%, H 7.12%, N 14.13%, O 24.21%
Literature References: Prepn: Halpern, Jones, J. Am. Pharm. Assoc. 38, 352 (1949); Snyder, Link, J. Am. Chem. Soc. 75, 1881 (1953).
Properties: Crystals from benzene + petr ether, mp 155°. Solubility (g/100 ml soln) in water 0.12; in alcohol 4.3; in ether 2.6. pH of satd aq solns: 5.6-5.7. pK 8.45: Fox, Shugar, Bull. Soc. Chim. Belg. 61, 44 (1952).
Melting point: mp 155°
pKa: pK 8.45: Fox, Shugar, Bull. Soc. Chim. Belg. 61, 44 (1952)
NOTE: This is a controlled substance (depressant): 21 CFR, 1308.13.
Therap-Cat: Anticonvulsant.
Keywords: Anticonvulsant.

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