Methdilazine
Title: Methdilazine
CAS Registry Number: 1982-37-2
CAS Name: 10-[(1-Methyl-3-pyrrolidinyl)methyl]-10H-phenothiazine
Molecular Formula: C18H20N2S
Molecular Weight: 296.43
Percent Composition: C 72.93%, H 6.80%, N 9.45%, S 10.82%
Literature References: Prepn: Feldkamp, Wu, US 2945855 (1960 to Mead Johnson). Toxicity data: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971).
Properties: Crystals, mp 87-88°.
Melting point: mp 87-88°
 
Derivative Type: Hydrochloride
CAS Registry Number: 1229-35-2
Trademarks: Dilosyn; Disyncran; Tacaryl (Westwood)
Molecular Formula: C18H20N2S.HCl
Molecular Weight: 332.89
Percent Composition: C 64.94%, H 6.36%, N 8.42%, S 9.63%, Cl 10.65%
Properties: Crystals from isopropyl alc, mp 187.5-189°. LD50 orally in rats: 320 mg/kg (Goldenthal).
Melting point: mp 187.5-189°
Toxicity data: LD50 orally in rats: 320 mg/kg (Goldenthal)
 
Therap-Cat: Antipruritic.
Keywords: Antipruritic.

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