Methoxyfenozide
Title: Methoxyfenozide
CAS Registry Number: 161050-58-4
CAS Name: 3-Methoxy-2-methylbenzoic acid 2-(3,5-dimethylbenzoyl)-2-(1,1-dimethylethyl)hydrazide
Additional Names: N¢-tert-butyl-N¢-(3,5-dimethylbenzoyl)-3-methoxy-2-methylbenzohydrazide; N-tert-butyl-N¢-(3-methoxy-o-toluoyl)-3,5-xylohydrazide
Manufacturers' Codes: RH-112485; RH-2485
Trademarks: Intrepid (Dow AgroSci.); Runner (Bayer CropSci.); Prodigy (Dow AgroSci.)
Molecular Formula: C22H28N2O3
Molecular Weight: 368.47
Percent Composition: C 71.71%, H 7.66%, N 7.60%, O 13.03%
Literature References: Synthetic nonsteroidal ecdysone agonist. Prepn: Z. Lidert et al., EP 602794; eidem, US 5530028 (1994, 1996 both to Rhom & Haas). Comparative insecticidal activity: A. Trisyono, G. M. Chippendale, J. Econ. Entomol. 90, 1486 (1997). Mechanism of action and metabolism: G. Smagghe et al., Pestic. Sci. 55, 386 (1999). Review of physical properties, biological activity and field studies: D. P. Le et al., Brighton Crop Prot. Conf. - Pests Dis. 1996, 481-486; of physical properties and insecticidal activity: G. R. Carlson et al., Pest Manage. Sci. 57, 115-119 (2001).
Properties: White powder, mp 204-205°. Vapor pressure (25°): <4.0 ´ 10-8 torr. Soly in water: 3.3 mg/l; in acetone: 9%. Soly (g/l): crop oil <10, cyclohexanone 90, DMSO 110, N-methylpyrrolidone 380, xylene <10. Soly in acetone 9%. LD50 in rats, mice (mg/kg): >5000, >5000 orally; in rats (mg/kg): >2000 dermally. LC50 in rats (mg/l): >4.3 by inhalation. LC50 (8 day dietary) in mallard duck, bobwhite quail (mg/kg diet): >5620, >5620. LC50 in bluegill sunfish, Daphnia magna (mg/l): >4.3 (96 hr); 3.7 (48 hr) (Le).
Melting point: mp 204-205°
Toxicity data: LD50 in rats, mice (mg/kg): >5000, >5000 orally; in rats (mg/kg): >2000 dermally; LC50 in rats (mg/l): >4.3 by inhalation; LC50 (8 day dietary) in mallard duck, bobwhite quail (mg/kg diet): >5620, >5620; LC50 in bluegill sunfish, Daphnia magna (mg/l): >4.3 (96 hr); 3.7 (48 hr) (Le)
Use: Insecticide.

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