N-Nitrosodiethylamine
Title: N-Nitrosodiethylamine
CAS Registry Number: 55-18-5
CAS Name: N-Ethyl-N-nitrosoethanamine
Additional Names: diethylnitrosamine
Trademarks: DEN; DENA; NDEA
Molecular Formula: C4H10N2O
Molecular Weight: 102.14
Percent Composition: C 47.04%, H 9.87%, N 27.43%, O 15.66%
Line Formula: (C2H5)2NNO
Literature References: Detected in trace amounts in tobacco smoke: Druckney, Preussman, Naturwissenschaften 49, 498 (1962) and in various processed foods: Hedler, Marquardt, Food Cosmet. Toxicol. 6, 341 (1968); Friemuth, Glaeser, Nahrung 14, 357 (1970). Formed by the interaction of nitrite with diethylamine and by the action of nitrate-reducing bacteria. Industrial prepn: Reilly, DE 1085166 (1960 to du Pont), C.A. 56, 4594h (1962); Levering, Maury, US 3090786 (1963 to Hercules Powder); Minisci, Galli, Chim. Ind. (Milan) 46, 173 (1964). Hepatotoxicity and carcinogenicity studies: Schmaehl et al., Naturwissenschaften 54, 341 (1967); Grover, Fischer, Eur. J. Cancer 7, 77 (1971); Bader et al., Arch. Geschwulstforsch. 37, 327 (1971). General review: Magee, Barnes, Adv. Cancer Res. 10, 163-246 (1967).
Properties: Slightly yellow liq. d420 0.9422. bp 175-177°. bp5 47°. nD20 1.4388. Sol in water, alc, ether.
Boiling point: bp 175-177°; bp5 47°
Index of refraction: nD20 1.4388
Density: d420 0.9422
CAUTION: This substance is reasonably anticipated to be a human carcinogen: Report on Carcinogens, Eleventh Edition (PB2005-104914, 2004) p III-198.
Use: Gasoline and lubricant additive; antioxidant; stabilizer in plastics.

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