p-Methyldiphenhydramine
Title: p-Methyldiphenhydramine
CAS Registry Number: 19804-27-4
CAS Name: N,N-Dimethyl-2-[(4-methylphenyl)phenylmethoxy]ethanamine
Additional Names: N,N-dimethyl-2-[(p-methyl-a-phenylbenzyl)oxy]ethylamine; b-dimethylaminoethyl 4-methylbenzhydryl ether; p-methylbenzhydryl 2-dimethylaminoethyl ether
Trademarks: Neo-Benodine; Toladryl
Molecular Formula: C18H23NO
Molecular Weight: 269.38
Percent Composition: C 80.26%, H 8.61%, N 5.20%, O 5.94%
Literature References: Prepn: Rieveschl, US 2527962 (1950 to Parke, Davis); GB 683483 (1952 to Fabriken Brocades-Stheeman & Pharmacia).
 
Derivative Type: Hydrochloride
Molecular Formula: C18H23NO.HCl
Molecular Weight: 305.84
Percent Composition: C 70.69%, H 7.91%, N 4.58%, O 5.23%, Cl 11.59%
Properties: Crystals from acetone, mp 150-152° (free base bp0.1 143°).
Melting point: mp 150-152°
Boiling point: free base bp0.1 143°
 
Therap-Cat: Antihistaminic.
Keywords: Antihistaminic; Aminoalkylethers.

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