Pentifylline
Title: Pentifylline
CAS Registry Number: 1028-33-7
CAS Name: 1-Hexyl-3,7-dihydro-3,7-dimethyl-1H-purine-2,6-dione
Additional Names: 1-hexyltheobromine; 1-hexyl-3,7-dimethylxanthine; 3,7-dimethyl-1-hexyl-1H,3H-purin-2,6-dione
Manufacturers' Codes: SK-7
Trademarks: Cosaldon (HMR)
Molecular Formula: C13H20N4O2
Molecular Weight: 264.32
Percent Composition: C 59.07%, H 7.63%, N 21.20%, O 12.11%
Literature References: Prepn from theobromine and hexyl halide: Eidebenz, Schuh, DE 860217 (1952 to Chem. Werke Albert); Serchi, Chimica 40, 451 (1964); Chkhikvadze et al., SU 202152 (1967), C.A. 69, 19368x (1968). Pharmacology: Cugurra, Echinard-Garin, Arch. Int. Pharmacodyn. Ther. 123, 481 (1960); Ramos et al., ibid. 153, 430 (1965); Mohler et al., Arzneim.-Forsch. 16, 1524 (1966). Metabolic studies: Mohler et al., Arch. Pharm. 299, 448 (1966).
Properties: Crystals, mp 82-83°.
Melting point: mp 82-83°
Use: Stabilizer of vitamin preparations: Nook, Eidebenz, DE 1810705 (1970 to Chem. Werke Albert).
Therap-Cat: Vasodilator.
Keywords: Vasodilator (Cerebral); Vasodilator (Peripheral).

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