Physalaemin
Title: Physalaemin
CAS Registry Number: 2507-24-6
CAS Name: Physalemin
Molecular Formula: C58H84N14O16S
Molecular Weight: 1265.44
Percent Composition: C 55.05%, H 6.69%, N 15.50%, O 20.23%, S 2.53%
Literature References: An undecapeptide belonging to the group of proteins named tachykinins. Found in skin of the amphibian Physalaemus fuscumaculatus: Erspamer et al., Experientia 18, 562 (1962). Structure: Erspamer et al., ibid. 20, 489 (1964); Anastasi et al., Arch. Biochem. Biophys. 108, 341 (1964). Synthesis: Bernardi et al., Experientia 20, 490 (1964); Nakamura et al., JP 71 25384 (1971 to Dainippon), C.A. 75, 152083r (1971). Solid-phase synthesis: W. Voelter et al., Tetrahedron 28, 5963 (1972). Biological activities similar to the tachykinins eledoisin and substance P, q.q.v. Exerts a powerful hypotensive action, stimulates salivary secretion, intestinal contraction, and vasodilation. Occurrence in other Physalaemus spp. and pharmacology: G. Bertaccini et al., Br. J. Pharmacol. 25, 363 (1965); G. Bertaccini, Pharmacol. Rev. 28, 127 (1976). Differentiation of physalaemin and substance P: Geipert et al., Arch. Pharmacol. 265, 225 (1969). Immunoreactivity study in human lung small-cell carcinoma: L. H. Lazarus et al., Science 219, 79 (1983).
 
Derivative Type: Trifluoroacetate dihydrate
Molecular Formula: C58H84N14O16S.CF3COOH.2H2O
Molecular Weight: 1415.49
Percent Composition: C 50.91%, H 6.34%, N 13.85%, O 22.61%, S 2.27%, F 4.03%
Properties: Dec 180°. [a]D20 -56° (c = 0.2 in ethanol). uv max: 278 nm (e 1780). Slowly loses activity when incubated in blood. Inactivated by liver and kidney homogenates.
Optical Rotation: [a]D20 -56° (c = 0.2 in ethanol)
Absorption maximum: uv max: 278 nm (e 1780)
 
Derivative Type: Hydrochloride trihydrate
Molecular Formula: C58H84N14O16S.HCl.3H2O
Molecular Weight: 1355.94
Percent Composition: C 51.38%, H 6.76%, N 14.46%, O 22.42%, S 2.36%, Cl 2.61%
Properties: Dec about 185°. [a]D25 -43° (c = 1 in 95% acetic acid).
Optical Rotation: [a]D25 -43° (c = 1 in 95% acetic acid)

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