TAPS
Title: TAPS
CAS Registry Number: 29915-38-6
CAS Name: 3-[[2-Hydroxy-1,1-bis(hydroxymethyl)ethyl]amino]-1-propanesulfonic acid
Additional Names: N-tris[(hydroxymethyl)methyl]-3-aminopropanesulfonic acid
Molecular Formula: C7H17NO6S
Molecular Weight: 243.28
Percent Composition: C 34.56%, H 7.04%, N 5.76%, O 39.46%, S 13.18%
Literature References: Zwitterionic N-substituted sulfonic acid in the style of the "Good" buffers; active in the pH range 6-8.5. Prepn: I. Zeid, I. Ismail, Ann. 1974, 667. Dissociation: A. M. El-Nady, H. A. Azab, Acta Chim. Hung. 130, 665 (1993). Use as eluent: R. H. P. Reid, J. Chromatogr. A 684, 221 (1994). Effect of buffer concentration on pH-activity relationship: C. G. Bevans, A. L. Harris, J. Biol. Chem. 274, 3711 (1999).
Properties: Crystals, mp 194°. pKa: 8.55; pKa (37°): 8.1; pKa2 (25°): 8.28.
Melting point: mp 194°
pKa: pKa: 8.55; pKa (37°): 8.1; pKa2 (25°): 8.28
 
Derivative Type: TAPSO
CAS Registry Number: 68399-81-5
CAS Name: 2-Hydroxy-3-[[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino]-1-propanesulfonic acid
Molecular Formula: C7H17NO7S
Molecular Weight: 259.28
Percent Composition: C 32.43%, H 6.61%, N 5.40%, O 43.19%, S 12.37%
Literature References: Hydroxy analog of TAPS. Prepn: W. J. Ferguson et al., Anal. Biochem. 104, 300 (1980). Crystal structure: J. Wouters, D. Stalke, Acta Crystallogr. C52, 1684 (1996). Thermodynamics of dissociation: R. N. Roy et al., J. Chem. Eng. Data 42, 446 (1997).
Properties: Triclinic colorless crystals, mp 226-228° (dec). pKa (20°): 7.7. DpKa/°C: -0.018. Soly in water (0°): 1M.
Melting point: mp 226-228° (dec)
pKa: pKa (20°): 7.7; pKa/°C: -0.018
 
Use: Biological buffer.

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