Thiopental Sodium
Title: Thiopental Sodium
CAS Registry Number: 71-73-8
CAS Name: 5-Ethyldihydro-5-(1-methylbutyl)-2-thioxo-4,6(1H,5H)-pyrimidinedione monosodium salt
Additional Names: 5-ethyl-5-(1-methylbutyl)-2-thiobarbituric acid sodium salt; thiomebumal sodium; penthiobarbital sodium; thiopentone sodium; thionembutal
Trademarks: Intraval Sodium (RPR); Nesdonal Sodium (RPR); Pentothal Sodium (Abbott); Trapanal (Byk Gulden)
Molecular Formula: C11H17N2NaO2S
Molecular Weight: 264.32
Percent Composition: C 49.98%, H 6.48%, N 10.60%, Na 8.70%, O 12.11%, S 12.13%
Literature References: Prepn: US 2153729 (1939); US 2876225 (1959). Prepn of nonhygroscopic crystals: Hartop, US 3109001 (1963 to Abbott). Acute toxicity: Christensen, Lee, Toxicol. Appl. Pharmacol. 26, 495 (1973). Comprehensive description: M. J. McLeish, Anal. Profiles Drug Subs. Excip. 21, 535-572 (1992).
Properties: Yellowish-white, hygroscopic powder. Alliaceous, garlic-like odor. Sol in water, alcohol. Insol in ether, benzene, petr ether. Aq solns are alkaline to litmus. Solns dec on standing; on boiling precipitation occurs. LD50 in mice (mg/kg): 149 i.p.; 78 i.v. (Christensen, Lee).
Toxicity data: LD50 in mice (mg/kg): 149 i.p.; 78 i.v. (Christensen, Lee)
NOTE: This is a controlled substance (depressant): 21 CFR, 1308.13.
Therap-Cat: Anesthetic (intravenous).
Therap-Cat-Vet: Short-acting anesthetic.
Keywords: Anesthetic (Intravenous).

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