Xylazine
Title: Xylazine
CAS Registry Number: 7361-61-7
CAS Name: N-(2,6-Dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine
Additional Names: 5,6-dihydro-2-(2,6-xylidino)-4H-1,3-thiazine; 2-(2,6-dimethylphenylamino)-4H-5,6-dihydro-1,3-thiazine
Manufacturers' Codes: Bay 1470; Bay Va 1470; Wh-7286
Molecular Formula: C12H16N2S
Molecular Weight: 220.33
Percent Composition: C 65.41%, H 7.32%, N 12.71%, S 14.55%
Literature References: Prepn: O. Behner et al., BE 634552 C.A. 61, 4369b (1964); eidem, DE 1173475 C.A. 61, 13323c (1964); eidem, US 3235550 (1964, 1964, 1966 all to Bayer). Pharmacology: G. Sagner et al., Dtsch. Tieraerztl. Wochenschr. 75, 565 (1968); Kroneberg, Schlossman, Arch. Pharmakol. Exp. Pathol. 268, 348 (1971). Metabolic studies: Duhm et al., Berl. Muench. Tieraerztl. Wochenschr. 82, 104 (1969). Veterinary clinical studies: Clarke, Hall, Vet. Rec. 85, 512 (1969); Burns, McMullan, Vet. Med. 67, 77 (1972).
Properties: Colorless, almost tasteless crystals from benzene-ligroin, mp 140-142°. Also reported as mp 136-139°. Soluble in dilute acids, benzene, acetone, chloroform; sparingly sol in petr ether. Practically insol in water, alkalies. LD50 in mice (mg/kg): 43 i.v.; 121 s.c.; 240 orally; LD50 in rats (mg/kg): 130 orally (Sagner).
Melting point: mp 140-142°; mp 136-139°
Toxicity data: LD50 in mice (mg/kg): 43 i.v.; 121 s.c.; 240 orally; LD50 in rats (mg/kg): 130 orally (Sagner)
 
Derivative Type: Hydrochloride
CAS Registry Number: 23076-35-9
Trademarks: Narcoxyl (Veterinaria); Rompun (Bayer); Solvazine (Solvay); Xylapan (Chassot); Xylasol (Graeub)
Molecular Formula: C12H16N2S.HCl
Molecular Weight: 256.79
Percent Composition: C 56.13%, H 6.67%, N 10.91%, S 12.49%, Cl 13.81%
 
Therap-Cat-Vet: Sedative, analgesic, muscle relaxant.

Others monographs:
FormestaneCirculinsAristolochic AcidSalvia
ImiquimodMenogarilCupric TartrateTrimethaphan Camsylate
ACVLunacrineDiazoacetic EsterMoxalactam
DipivefrinSodium SulfateOxymethureaα-Erythroidine
©2016 DrugLead US FDA&EMEA