Title: Calcineurin
CAS Registry Number: 9025-75-6
CAS Name: Phosphoprotein phosphatase
Literature References: Ca2+/calmodulin dependent ser-thr phosphatase that participates in many signalling pathways involved in gene regulation or biological responses to external stimuli in various organisms and cell types. Highly conserved heterodimer from yeast to humans comprised of a 58-69 kDa catalytic and calmodulin binding subunit A, calcineurin A, and a 16-19 kDa regulatory subunit B, calcineurin B. Isoln: J. H. Wang, R. Desai, Biochem. Biophys. Res. Commun. 72, 926 (1976). Purification: C. B. Klee, M. H. Krinks, Biochemistry 17, 120 (1978); and phosphatase activity: C. B. Klee et al., Proc. Natl. Acad. Sci. USA 76, 6270 (1979). Review of early work: C. B. Klee, J. Haiech, Ann. N.Y. Acad. Sci. 1980, 43-54; of role in neuronal cells and brain injury: M. Morioka et al., Prog. Neurobiol. 58, 1-30 (1999). Review of structure and function: C. B. Klee et al., J. Biol. Chem. 273, 13367-13370 (1998); J. Aramburu et al., Curr. Top. Cell. Regul. 36, 237-295 (2000).

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