Title: Endothelin
CAS Registry Number: 117399-94-7
Additional Names: Endothelin-1; ET-1
Literature References: Potent vasoconstrictor peptide produced by mammalian vascular endothelial cells; present in low concentrations in normal serum. Composed of 21 amino acid residues; mol wt ~2500 Da. Isoln, characterization and cloning of porcine endothelin: M. Yanagisawa et al., Nature 332, 411 (1988). Structural identity of porcine and human endothelin: Y. Itoh et al., FEBS Lett. 231, 440 (1988). Structural similarity with the snake venom toxins, sarafotoxins S6: C. Y. Lee, V. A. Chiappinelli, Nature 335, 303 (1988); C. Takasaki et al., ibid. 303. Identification in serum by radioimmunoassay: K. Ando et al., FEBS Lett. 245, 164 (1989). Two additional isoforms, known as endothelin-2 and endothelin-3, have been identified. Structures and comparative pharmacology of human endothelin isopeptides: A. Inoue et al., Proc. Natl. Acad. Sci. USA 86, 2863 (1989). Mechanism of action study: Y. Hirata et al., Biochem. Biophys. Res. Commun. 154, 868 (1988). Possible role in acute renal failure: J. D. Firth et al., Lancet 2, 1179 (1988). In vivo effects on pulmonary and systemic hemodynamics: H. L. Lippton et al., J. Appl. Physiol. 66, 1008 (1989). Review: T. Masaki, J. Cardiovasc. Pharmacol. 13, Suppl. 5, S1-S4 (1989).

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