Metitepine
Title: Metitepine
CAS Registry Number: 20229-30-5
CAS Name: 1-[10,11-Dihydro-8-(methylthio)dibenzo[b,f]thiepin-10-yl]-4-methylpiperazine
Additional Names: 8-methylthio-10-(4-methylpiperazino)-10,11-dihydrodibenzo[b,f]thiepine; methiothepine; methiothepin
Manufacturers' Codes: Ro-8-6837
Molecular Formula: C20H24N2S2
Molecular Weight: 356.55
Percent Composition: C 67.37%, H 6.78%, N 7.86%, S 17.99%
Literature References: Serotonin (5-HT2) receptor antagonist; also exhibits affinity for 5-HT1-receptors. Prepn: NL 6608618; M. Protiva et al., US 3379729 (1966, 1968 both to SPOFA); and pharmacology: K. Pelz et al., Collect. Czech. Chem. Commun. 33, 1895 (1968); J. O. Jilek et al., ibid. 39, 3338 (1974). Receptor-blocking study: M.-A. Monachon et al., Arch. Pharmacol. 274, 192 (1972). Use in classification of 5-HT receptors: P. B. Bradley et al., Neuropharmacology 25, 563 (1986); E. J. Mylecharane, Clin. Exp. Pharmacol. Physiol. 16, 517 (1989).
Properties: Crystals from ethanol, mp 88-89°.
Melting point: mp 88-89°
 
Derivative Type: Maleate
CAS Registry Number: 19728-88-2
Molecular Formula: C20H24N2S2.C4H4O4
Molecular Weight: 472.62
Percent Composition: C 60.99%, H 5.97%, N 5.93%, S 13.57%, O 13.54%
Properties: Crystals from ethanol, mp 171-173°. LD5O in mice (mg/kg): 51 i.v.; 94 orally (Jilek).
Melting point: mp 171-173°
Toxicity data: LD5O in mice (mg/kg): 51 i.v.; 94 orally (Jilek)
 
Use: Biochemical tool in serotonin receptor binding studies.

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