Monuron
Title: Monuron
CAS Registry Number: 150-68-5
CAS Name: N¢-(4-Chlorophenyl)-N,N-dimethylurea
Additional Names: 1,1-dimethyl-3-(p-chlorophenyl)urea; CMU
Trademarks: Karmex Monuron Herbicide; Telvar (DuPont)
Molecular Formula: C9H11ClN2O
Molecular Weight: 198.65
Percent Composition: C 54.42%, H 5.58%, Cl 17.85%, N 14.10%, O 8.05%
Literature References: Prepd by reacting p-chlorophenyl isocyanate with dimethylamine: Bucha, Todd, Science 114, 493 (1951); see also US 2655444; US 2655445; US 2655446; US 2655447. Toxicity study: G. W. Bailey, J. L. White, Residue Rev. 10, 97 (1965). Review: McCall, Agric. Chem. 7, 40 (1952).
Properties: Thin rectangular prisms from methanol, mp 170.5-171.5° (the commercial product melts at 176-177°). Vapor pressure at 25°: 5 ´ 10-7 mm; at 100°: 178 ´ 10-5 mm. Slight odor. Stable toward oxygen and moisture under ordinary conditions at neutral pH; elevated temps and more acid or alkaline conditions appreciably raise rate of hydrolysis. Very slightly sol in water and in no. 3 Diesel oil: About 230 ppm at 25°. pH of satd aq soln 6.26. Moderately sol in methanol, ethanol, acetone. Practically insol in hydrocarbon solvents. LD50 orally in rats: 3700 mg/kg (Bailey, White).
Melting point: mp 170.5-171.5° (the commercial product melts at 176-177°)
Toxicity data: LD50 orally in rats: 3700 mg/kg (Bailey, White)
 
Derivative Type: Trichloroacetate
Additional Names: Monuron TCA
Trademarks: Urox (Allied)
Molecular Formula: C9H11ClN2O.C2HCl3O2
Molecular Weight: 362.04
Percent Composition: C 36.49%, H 3.34%, Cl 39.17%, N 7.74%, O 13.26%
Literature References: Prepn: Gilbert et al., US 2782112 (1957 to Allied Chem.). Effective in control of both weeds and grasses.
Properties: mp 78-81°.
Melting point: mp 78-81°
 
CAUTION: Anemia and methemoglobinemia have been produced in experimental animals.
Use: Herbicide.

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