N,N-Diethylphenylacetamide
Title: N,N-Diethylphenylacetamide
CAS Registry Number: 2431-96-1
CAS Name: N,N-Diethylbenzeneacetamide
Additional Names: DEPA
Molecular Formula: C12H17NO
Molecular Weight: 191.27
Percent Composition: C 75.35%, H 8.96%, N 7.32%, O 8.36%
Literature References: Substituted amide with broad spectrum repellent activity. Prepn: G. Hausknecht, Ber. 22, 324 (1889); R. Mukherjee, J. Chem. Soc. D 1971, 1113; and structure-activity relationship studies: M. V. S. Suryanarayana et al., J. Pharm. Sci. 80, 1055 (1991). Comparative studies with deet and dimethyl phthalate, q.q.v., vs mosquitoes, black flies and land leeches: S. Kumar et al., Indian J. Med. Res. 80, 541 (1984); vs bedbugs: idem et al., ibid. 102, 20 (1995); vs rat flea: K. K. Mathur et al., ibid. 83, 466 (1986); vs sandflies: M. Kalyanasundaram et al., Med. Vet. Entomol. 8, 68 (1994). Comparison with deet and dibutyl phthalate, q.q.v., in prevention of scrub typhus: R. Tilak et al., Indian J. Med. Res. 113, 98 (2001). GC determn in urine: S. S. Rao et al., J. Chromatogr. B 493, 210 (1989). Toxicity and metabolism studies: idem. et al., Toxicology 58, 81 (1989); idem et al., Toxicol. Lett. 45, 67 (1989). Development of polysiloxane based slow release formulations and efficacy vs mosquitoes : D. C. Gupta et al., J. Polym. Mater. 17, 215 (2000). Review: S. S. Rao, K. M. Rao, J. Med. Entomol. 28, 303-306 (1991).
Properties: Liquid, bp0.3 120-122°. Log P (methanol/water): 2.40. Vapor pressure at 30°: 0.1043 cm Hg. LD50 in guinea pigs, rats, rabbits, mice (g/kg): 7, 3-4, 3.5, ~2 dermally (Rao, 1991).
Boiling point: bp0.3 120-122°
Log P: Log P (methanol/water): 2.40
Toxicity data: LD50 in guinea pigs, rats, rabbits, mice (g/kg): 7, 3-4, 3.5, ~2 dermally (Rao, 1991)
Use: Insect repellent.

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