Protionamide
Title: Protionamide
CAS Registry Number: 14222-60-7
CAS Name: 2-Propyl-4-pyridinecarbothioamide
Additional Names: 2-propylthioisonicotinamide; prothionamide; 2-propyl-4-thiocarbamoylpyridine
Trademarks: Ektebin (Hefa); Peteha (Fatol); Trevintix (Thžaplix)
Molecular Formula: C9H12N2S
Molecular Weight: 180.27
Percent Composition: C 59.96%, H 6.71%, N 15.54%, S 17.79%
Literature References: Prepn: D. Liberman et al., Compt. Rend. 242, 2409 (1956); GB 800250, D. Liberman, US 2901488 (1958, 1959 both to Chimie et Atomistique); L. N. Yakhontov et al., Khim. Farm. Zh. 10, 96 (1976), C.A. 85, 32787h (1976). Pharmacology: A. M. Il'in, Farmakol. Toksikol. 38, 471 (1975).
Properties: Crystals, mp 142°. Sol in ethanol, methanol; slightly sol in ether, chloroform. Practically insol in water. LD50 in mice, rats (g/kg): 1.0, 1.32 orally (Il'in).
Melting point: mp 142°
Toxicity data: LD50 in mice, rats (g/kg): 1.0, 1.32 orally (Il'in)
Therap-Cat: Antibacterial (tuberculostatic).
Keywords: Antibacterial (Tuberculostatic).

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