Resistomycin
Title: Resistomycin
CAS Registry Number: 20004-62-0
CAS Name: 3,5,7,10-Tetrahydroxy-1,1,9-trimethyl-2H-benzo[cd]pyrene-2,6(1H)-dione
Manufacturers' Codes: X-340
Molecular Formula: C22H16O6
Molecular Weight: 376.36
Percent Composition: C 70.21%, H 4.29%, O 25.51%
Literature References: Unusually stable antibiotic substance produced by Streptomyces resistomycificus: Brockmann, Schmidt-Kastner, Naturwissenschaften 38, 479 (1951); Ber. 87, 1460 (1954); Brockmann, DE 888918 (1953). Structure: Brockmann, Angew. Chem. 76, 863 (1964). Revised structure: Bailey et al., Chem. Commun. 1968, 374; Brockmann et al., Ber. 102, 1224 (1969). Synthetic studies: J. F. Kingston, L. Weiler, Can. J. Chem. 55, 785 (1977); K. James, R. A. Raphael, Tetrahedron Lett. 1979, 3895. Total synthesis: B. A. Keay, R. Rodrigo, J. Am. Chem. Soc. 104, 4725 (1982). Isoln from Streptomyces griseoflavus B71, 13C-NMR and biosynthesis: G. Höfle, H. Wolf, Ann. 1983, 835.
Properties: Yellow needles from dioxane, dec 315°. Sublimes at 200-205° (10-4 mm) without activity loss. Stable to hot conc H2SO4 or hot N KOH. Weakly acid. Absorption max: 268, 290, 320, 337, 366, 457 nm (e 24000, 23000, 14400, 13900, 11000, 15400). Slight soly in water; fair in ether, benzene, alcohol, acetone, acetic acid. Orange-red in sodium hydroxide and piperidine; red in pyridine. Fluoresces in alcohol, benzene, and acetone solns, also in sulfuric acid.
Absorption maximum: Absorption max: 268, 290, 320, 337, 366, 457 nm (e 24000, 23000, 14400, 13900, 11000, 15400)
NOTE: The name Resistomycin is also used as a trademark for Kanamycin A sulfate.

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