Salinazid
Title: Salinazid
CAS Registry Number: 495-84-1
CAS Name: [(2-Hydroxyphenyl)methylene]hydrazide 4-pyridinecarboxylic acid
Additional Names: 1-isonicotinoyl-2-salicylidenehydrazine; isonicotinic acid salicylidenehydrazide; saliniazid; N¢-o-hydroxybenzylidenepyridine-4-carboxyhydrazide; o-hydroxybenzal isonicotinylhydrazone
Trademarks: Nupa-Sal (Smith & Nephew); Acozid (ACO)
Molecular Formula: C13H11N3O2
Molecular Weight: 241.25
Percent Composition: C 64.72%, H 4.60%, N 17.42%, O 13.26%
Literature References: Prepd by the interaction of isoniazid and salicyl-aldehyde in water: Hart et al., Antibiot. Chemother. 4, 803 (1954); cf. Yale et al., J. Am. Chem. Soc. 75, 1933 (1953). Tuberculostatic activity and toxicity: Bavin et al., J. Pharm. Pharmacol. 7, 1032 (1955).
Properties: Crystals from ethanol, mp 232-233° (also given as 251°). Soly at 25° in 100 ml water: 0.005 g; in 100 ml abs ethanol: 0.18 g; in 100 ml propylene glycol: 0.212 g. Sol in dil aq acids and alkalies forming a yellow soln.
Melting point: mp 232-233° (also given as 251°)
Therap-Cat: Antibacterial (tuberculostatic).
Keywords: Antibacterial (Tuberculostatic).

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