Tranilast
Title: Tranilast
CAS Registry Number: 53902-12-8
CAS Name: 2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino]benzoic acid
Additional Names: N-(3¢,4¢-dimethoxycinnamoyl)anthranilic acid
Manufacturers' Codes: N-5¢
Trademarks: Rizaben (Kissei)
Molecular Formula: C18H17NO5
Molecular Weight: 327.33
Percent Composition: C 66.05%, H 5.23%, N 4.28%, O 24.44%
Literature References: Orally active anti-allergic agent. Prepn: K. Harita et al., DE 2402398; idem, US 3940422 (1974, 1976 both to Kissei). Pharmacological properties: H. Azuma et al., Br. J. Pharmacol. 58, 483 (1976). Mechanism of action study: Y. Iijima et al., Biochem. Biophys. Res. Commun. 93, 912 (1980). Clinical study in pediatric bronchial asthma: H. Shioda, Allergy 34, 213 (1979). Toxicity studies: M. Nakazawa et al., Oyo Yakuri 12, 385, 407 (1976), C.A. 88, 115327-8 (1978). Series of articles on teratogenicity tests: Iyakuhin Kenkyu 9, 148-193 (1978), C.A. 88, 130930f, 146300m-303q (1978).
Properties: Crystals from chloroform, mp 211-213°. LD50 in male, female mice, male, female rats (mg/kg): 780, 680, 1600, 1100 orally; 410, 385, 405, 395 i.p.; 2630, 2820, 3630, 3060 s.c. (Nakazawa, p 385).
Melting point: mp 211-213°
Toxicity data: LD50 in male, female mice, male, female rats (mg/kg): 780, 680, 1600, 1100 orally; 410, 385, 405, 395 i.p.; 2630, 2820, 3630, 3060 s.c. (Nakazawa, p 385)
Therap-Cat: Antiallergic.
Keywords: Antiallergic.

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