Letosteine
Title: Letosteine
CAS Registry Number: 53943-88-7
CAS Name: 2-[2-[(2-Ethoxy-2-oxoethyl)thio]ethyl]-4-thiazolidinecarboxylic acid
Additional Names: 2-[2-[(carboxymethyl)thio]ethyl]-4-thiazolidinecarboxylic acid 2-ethyl ester
Trademarks: Viscotiol (Erba)
Molecular Formula: C10H17NO4S2
Molecular Weight: 279.38
Percent Composition: C 42.99%, H 6.13%, N 5.01%, O 22.91%, S 22.95%
Literature References: Cyclic cysteine derivative. Prepn: M. X. Chodkiewicz, DE 2410307; eidem, US 4032534 (1974, 1979 to Ferlux-Chemie). Effect on viscoelasticity of mucus: E. Puchelle et al., Eur. J. Respir. Dis. 61 (Suppl 110), 195 (1980). In treatment of bronchitis: V. Macquet et al., Lille Med. 24, 735 (1979); P. Freour, J. Vergeret, Bordeaux Med. 12, 1553 (1979); P. Freour, ibid. 13, 1431 (1980); P. Meroni et al., Clin. Ter. 105, 109 (1983). Comparison with sulfur-containing compounds in bronchitis: D. Rodde, C.R. Ther. Pharmacol. Clin. 1(5), 31 (1983).
Properties: Crystals from ethanol, mp 142°.
Melting point: mp 142°
Therap-Cat: Mucolytic.
Keywords: Mucolytic.

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